Disordered and Increased Adrenocorticotropin Secretion with Diminished Adrenocorticotropin Potency in Obese in Premenopausal Women
نویسندگان
چکیده
منابع مشابه
Disordered adrenocorticotropin secretion in women with major depression.
CONTEXT Major depression is accompanied by activation of the hypothalamic pituitary axis and evidence of abnormalities in circadian and ultradian hormone rhythms. In addition, diminished negative feedback of cortisol on ACTH has been found. OBJECTIVE The objective of the study was to compare ACTH and cortisol hormonal patterns in women with major depression with normal control women. DESIGN...
متن کاملDiminished adrenal sensitivity and ACTH efficacy in obese premenopausal women.
BACKGROUND The ACTH-cortisol axis in women is activated and associated with decreased ACTH potency, estimated by relating ACTH and cortisol pulse masses. Recently, a new accurate method for constructing the endogenous dose-response relationship was introduced, which is based on the relation between ACTH concentrations and associated cortisol secretion rates within cortisol bursts. HYPOTHESIS ...
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Previous work showed that the stimulation by acetylcholine or pancreozymin of the secretion of digestive enzymes from the pancreas, and the stimulation by acetylcholine or adrenaline of the secretion of amylase and mucin from salivary glands was accompanied by an increased incorporation of P32 into the phospholipides of the tissues (l-4). This suggested that the phospholipides play a role in th...
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Enterostatins [Val-Pro-Asp-Pro-Arg (VPDPR), Val-Pro-Gly-Pro-Arg (VPGPR), and Ala-Pro-Gly-Pro-Arg (APGPR)] are pentapeptides derived from the NH2-terminus of procolipase after tryptic cleavage and belong to the family of gut-brain peptides. Although enterostatin-like immunoreactivities exist in blood, brain, and gut, and exogenous enterostatins decrease fat appetite and insulin secretion in rats...
متن کاملArginine Vasopressin Potentiates Adrenocorticotropin
A bstract. Arginine vasopressin (AVP) stimulates ACTH release in man and acts synergistically with synthetic ovine corticotropin-releasing factor (oCRF) in vitro. This study was designed to examine in man the combined effects of synthetic AVP (10 U intramuscularly) and oCRF (1 gg/kg intravenously) on ACTH release. Five normal male volunteers participated in five separate experiments: (a) AVP al...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2009
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2009-0350